/* THEME */
@font-face {
  font-family: 'Poppins';
  src: url("../fonts/Poppins-Light.ttf") format("ttf");
}

@font-face {
  font-family: 'Open Sans Bold';
  src: url('../fonts/OpenSans-Bold.ttf');
}

@font-face {
  font-family: 'Open Sans';
  src: url('../fonts/OpenSans-Regular.ttf');
}

@font-face {
  font-family: 'Arial';
  src: url('../fonts/Lato-Regular.ttf');
}

@font-face {
  font-family: 'Open Sans SemiBold';
  src: url('../fonts/OpenSans-SemiBold.ttf');
}

@font-face {
  font-family: 'Gotham';
  src: url('../fonts/GothamMedium.ttf');
}

@font-face {
  font-family: 'Knockout HTF49-Liteweight';
  src: url('../fonts/Oswald-Bold.otf');
}

@font-face {
  font-family: 'Knockout HTF30-JuniorWelterwt';
  src: url('../fonts/Oswald-Regular.otf');
}

@font-face {
  font-family: "Knockout";
  src: url("../fonts/Oswald-Regular.woff2") format("woff2"), url("../fonts/Oswald-Regular.woff") format("woff");
  font-weight: 200;
  font-style: normal;
  font-display: swap;
}

@font-face {
  font-family: "Knockout";
  src: url("../fonts/Oswald-Regular.woff2") format("woff2"), url("../fonts/Oswald-Regular.woff") format("woff");
  font-weight: 400;
  font-style: normal;
  font-display: swap;
}

@font-face {
  font-family: "Knockout";
  src: url("../fonts/Oswald-Medium.woff2") format("woff2"), url("../fonts/Oswald-Medium.woff") format("woff");
  font-weight: 700;
  font-style: normal;
  font-display: swap;
}

@font-face {
  font-family: "Knockout";
  src: url("../fonts/Oswald-Bold.woff2") format("woff2"), url("../fonts/Oswald-Bold.woff") format("woff");
  font-weight: 800;
  font-style: normal;
  font-display: swap;
}

@font-face {
  font-family: 'icomoon';
  src: url("../fonts/icomoon.ttf?84ga1f") format("truetype");
  font-weight: normal;
  font-style: normal;
}

@font-face {
  font-family: "ShellPortal-iconfont";
  src: url("../fonts/ShellPortal-iconfont.eot");
  src: url("../fonts/ShellPortal-iconfont.eot?#iefix") format("eot"), url("../fonts/ShellPortal-iconfont.woff2") format("woff2"), url("../fonts/ShellPortal-iconfont.woff") format("woff"), url("../fonts/ShellPortal-iconfont.ttf") format("truetype"), url("../fonts/ShellPortal-iconfont.svg#ShellPortal-iconfont") format("svg");
}

.icon-icon-angle-right:before,
.icon-icon-card:before, .icon-icon-check:before,
.icon-icon-checkbox-checked:before,
.icon-icon-checkbox-error-off:before,
.icon-icon-checkbox-off:before,
.icon-icon-checkbox-on:before,
.icon-icon-checkbox-unchecked:before,
.icon-icon-close:before,
.icon-icon-computer:before,
.icon-icon-download:before,
.icon-icon-earth:before, .icon-icon-eye-closed:before,
.icon-icon-eye:before,
.icon-icon-firstaid:before,
.icon-icon-hamburger:before,
.icon-icon-info:before,
.icon-icon-invalid:before,
.icon-icon-link:before,
.icon-icon-linkedin:before,
.icon-icon-logout:before, .icon-icon-mail:before,
.icon-icon-next:before, .icon-icon-phone:before,
.icon-icon-profile-hcp:before,
.icon-icon-profile:before,
.icon-icon-red-down-arrow:before,
.icon-icon-search:before,
.icon-icon-settings:before,
.icon-icon-twitter:before, .icon-icon-up:before, .icon-icon-valid:before, .icon-info_language:before, .icon-Warning:before, .icon-white-check:before, .icon-wrong:before, .icon-phone:before, .icon-mail:before, .icon-profile-hcp:before, .icon-close:before, .icon-menu:before, .icon-settings:before, .icon-logout:before {
  font-family: "ShellPortal-iconfont", serif;
  -webkit-font-smoothing: antialiased;
  -moz-osx-font-smoothing: grayscale;
  font-style: normal;
  font-variant: normal;
  font-weight: normal;
  text-decoration: none;
  text-transform: none;
}

.icon-icon-search:before {
  content: "";
}

html,
body,
* {
  font-family: 'Open Sans', sans-serif;
}

/* Menu header */
header.global-header {
  position: fixed;
  z-index: 99;
  top: 0;
}

.navigation-header {
  display: flex;
  justify-content: space-between;
  padding: 14px 0;
}

.global-header__item .worldwide {
  display: -webkit-box;
  display: -webkit-flex;
  display: -ms-flexbox;
  display: flex;
  font-size: 12px;
}

.icon__text {
  width: 1em;
  height: 1em;
  margin-right: 0.3em;
  position: relative;
  top: 0.15em;
}

.global-header__item .worldwide a {
  text-decoration: none;
  color: #000000;
  cursor: pointer;
}

.global-header__item .worldwide a:hover,
.global-header__item .worldwide a:focus {
  text-decoration: none;
  color: #ff0000;
}

.countryselector__url {
  text-transform: uppercase;
}

.global-header__item .worldwide a span.icon__text {
  top: 4px;
  margin-right: 2px;
}

.global-header__item .worldwide a span.icon__text:before {
  width: 18px;
  height: 18px;
  display: inline-block;
}

.icon-earth:before {
  content: url(../images/icon-earth.svg);
}


@media screen and (max-width: 768px) {
  .global-header__item .worldwide a span.link__text {
    display: none;
  }

  header .navbar {
    flex-wrap: nowrap;
  }

  .global-header__item .worldwide a span.icon__text {
    top: 0;
    margin-right: 5px;
  }
}

.dropdown.icon-profile-hcp {
  position: static;
  padding: 0;
}

.icon-profile-hcp:before {
  content: "";
  width: 59px;
  height: 56px;
  display: inline-block;
  background-image: url("../images/icon-user.png");
  background-repeat: no-repeat;
  background-size: 100%;
}

.global-header-item {
  display: flex;
}

.dropdown-icon {
  position: relative;
  cursor: pointer;
}

.dropdown-icon .menu {
  display: none;
  position: absolute;
  top: 100%;
  left: auto;
  right: -1px;
  opacity: 0;
  border: 1px solid #bcbcbc;
  z-index: 2;
  -webkit-transition: max-height 0.5s ease-out;
  transition: max-height 0.5s ease-out;
}

.user-name-profile-hcp {
  color: #666666;
  padding: 12px;
  display: block;
}

.dropdown-icon.accessible-hover>.menu {
  display: block;
  min-width: 230px;
  opacity: 1;
  padding: 0;
  right: 0;
  outline: 1px solid #dddddd;
  border: none;
  -webkit-box-shadow: 0px 1px 6px 0px rgb(0 0 0 / 20%);
  box-shadow: 0px 1px 6px 0px rgb(0 0 0 / 20%);
  background: #fff;
}

.dropdown-icon.accessible-hover>.menu:before {
  content: "";
  border-bottom: 11px solid #ececec;
  border-left: 9px solid transparent;
  border-right: 7px solid transparent;
  position: absolute;
  width: 0;
  height: 0;
  right: 21px;
  top: -12px;
}

.dropdown-icon.accessible-hover>.menu:after {
  border-bottom: 10px solid #fff;
  border-left: 7px solid transparent;
  border-right: 7px solid transparent;
  position: absolute;
  content: "";
  width: 0;
  height: 0;
  right: 21px;
  top: -10px;
}

.dropdown-icon,
.header-menu-search {
  display: flex;
  align-items: center;
}

main.main-content-body {
  padding-top: 85px;
}

.menu--dropdown .menu-group__list {
  margin: 0;
  padding: 0;
  height: auto;
  color: black;
  text-indent: 0;
}

.menu-group__list {
  margin-bottom: 0;
}

.menu-group__item .menu-item {
  color: #666666;
  width: 100%;
  display: block;
  font-size: 14px;
  padding: 12px;
}

.menu-group__item .menu-item:hover {
  text-decoration: none;
}

.icon-icon-logout:before {
  content: "";
}

.menu--dropdown .menu-group__item {
  width: 100%;
  border-right: 0;
  min-height: auto !important;
  padding: 10px;
}

li.nav-item:last-of-type {
  margin-right: 0;
}

.nav-item a:hover {
  text-decoration: none;
  color: #E50019;
}

.nav-item>a {
  font-weight: 600;
  font-size: 14px;
  line-height: 21px;
  color: #333333;
}

.nav-item>a.is-active {
  color: #E50019;
}

.breadcrumb {
  background: none;
  padding: 0;
  margin-top: 22px;
}

.breadcrumb ol {
  display: inline-block;
  align-items: center;
}

.breadcrumb ol li {
  display: block;
  float: left;
}

.breadcrumb ol li:not(:first-of-type) {
  padding-top: 2px;
}

.breadcrumb li:before {
  content: '';
  border: solid #BDBDBD;
  border-width: 0 2px 2px 0;
  display: inline-block;
  padding: 4px;
  transform: rotate(-45deg);
  -webkit-transform: rotate(-45deg);
  margin-right: 5px;
  margin-left: 5px;
}

.caption {
  position: absolute;
  top: 50%;
  left: 0;
  transform: translate(50%, -50%);
  max-width: 510px;
}

.btn-call-to-action {
  font-weight: 600;
  font-size: 17px;
  line-height: 26px;
  color: #FFFFFF;
  margin-top: 50px;
  background: #E50019;
  border-radius: 4px;
}

a.btn-call-to-action:hover {
  color: #FFFFFF;
}

h1.banner-title {
  font-weight: 400;
  font-size: 64px;
  line-height: 100%;
  text-transform: initial;
  color: #FFFFFF;
  max-width: 510px;
}

.banner-description {
  font-style: normal;
  font-weight: 400;
  font-size: 16px;
  line-height: 140%;
  color: #FFFFFF;
  max-width: 510px;
  -webkit-line-clamp: 4;
  line-clamp: 4;
}

.carousel-item {
  background-size: 100% 100%;
  background-repeat: no-repeat;
}

.article-item a:hover {
  color: #333333;
  text-decoration: none;
}

.article-item .article-title {
  font-weight: 600;
  font-size: 20px;
  line-height: 30px;
  color: #333333;
  margin-top: 0px;
  margin-bottom: 5px;
}

.article-item .article-description {
  font-weight: 400;
  font-size: 14px;
  line-height: 24px;
  color: #828282;
}

.section-brochure {
  background: #F6F6F6;
  border: 1px solid #EAEAEA;
}

.brochure-wrapper {
  display: flex;
  align-items: center;
  justify-content: space-between;
  padding: 3rem 6rem;
}

h1.brochure-title {
  font-weight: 700;
  font-size: 32px;
  line-height: 48px;
  color: #333333;
  margin: 0;
}

.btn-brochure-access {
  background: #E50019;
  font-weight: 600;
  font-size: 17px;
  line-height: 26px;
  color: #FFFFFF;
  padding: 18px 70px;
}

a.btn-brochure-access:hover {
  color: #FFFFFF;
}

@media screen and (max-width: 768px) {
  .brochure-wrapper {
    display: flex;
    align-items: flex-start;
    flex-direction: column;
    padding: 3rem 1rem;
  }
}

.right-footer {
  display: flex;
  flex-direction: column;
  justify-content: space-around;
  align-items: flex-end;
}

.path-takeda-products .product-listing-area a {
  color: black;
}

.js-form-item.form-item.js-form-type-select.form-type-select.js-form-item-product-category.form-item-product-category {
  width: 100%;
}

label[for="edit-product-category"] {
  display: none;
}

input#edit-submit-product-ta {
  display: none;
}

select#edit-product-category {
  width: 100%;
  border: unset;
  -webkit-appearance: none;
  -moz-appearance: none;
  background: transparent;
  background-image: url("data:image/svg+xml;utf8,<svg fill='black' height='24' viewBox='0 0 24 24' width='24' xmlns='http://www.w3.org/2000/svg'><path d='M7 10l5 5 5-5z'/><path d='M0 0h24v24H0z' fill='none'/></svg>");
  background-repeat: no-repeat;
  background-position-x: 100%;
  padding-left: 12px;
}

select#edit-product-category:focus {
  outline: none;
}

.product-listing-area .product-listing-dropdown .form-item,
.form-actions {
  margin-top: 1em;
  margin-bottom: 1em;

}

.product-listing-dropdown {
  padding: unset;
}

@media screen and (max-width: 992px) {
  .subscription-banner input#edit-email {
    width: 100%;
  }
}

.webform-submission-form.webform-submission-add-form .webform-button--submit.button {
  border-radius: unset;
  margin-left: unset;
}

.mainbox {
  margin: 75px auto;
  min-height: 344px;
  max-width: 656px;
  width: 100%;
}

.mainbox .err {
  font-family: 'Open Sans', sans-serif;
  font-style: normal;
  font-weight: 700;
  font-size: 160px;
  line-height: 100%;
  display: flex;
  align-items: center;
  text-align: center;
  letter-spacing: 0.01em;
  color: #000000;
  margin-bottom: 40px;
}

.mainbox .msg {
  text-align: center;
  margin-bottom: 24px;
}

.mainbox .msg h1 {
  font-weight: 700;
  font-size: 24px;
  line-height: 140%;
  color: #333333;
}

.mainbox .msg p {
  font-weight: 325;
  font-size: 16px;
  line-height: 24px;
  letter-spacing: 0.01em;
  color: #121212;
  margin: 0;
}

.mainbox .btn-wrapper {
  display: flex;
  justify-content: center;
}

.mainbox .btn-wrapper .btn {
  padding: 18px 15px;
  border-radius: 0;
  font-weight: 700;
  font-size: 16px;
  line-height: 140%;
  text-align: center;
  text-transform: uppercase;
}

.mainbox .btn-wrapper .btn.btn-primary {
  padding: 18px 34px;
}

.mainbox .btn-wrapper .btn:first-of-type {
  margin-right: 30px;
}

.page-min-height {
  min-height: 44vh;
}

@media screen and (max-width: 500px) {
  .mainbox .btn-wrapper {
    flex-direction: column-reverse;
  }

  .mainbox .btn-wrapper .btn:first-of-type {
    margin-right: 0;
    margin-top: 20px;
  }
}


.btn-primary-color {
  background: #FD0008;
  color: #FFFFFF;
}

.btn-primary-color:hover,
.btn-primary-color:active {
  color: #FFFFFF;
  background-color: #B10006;
}

.font-w-400 {
  font-weight: 400!important;
}

.font-w-500 {
  font-weight: 500!important;
}

.header-logo {
  max-width: 157px;
}
@media screen and (min-width: 1200px) {
  #user-register-form div[id^="edit-field-first-name-wrapper"], #user-register-form div[id^="edit-field-last-name-wrapper"] {
    width: 100%!important;
    display: block!important;
  }
  #user-register-form div[id^="edit-field-first-name-wrapper"] {
    margin-right: 0!important;
  }
}
/************************************/
.hd-external-link-overlay.d-none {
  display: none!important;
}
.hd-external-link-overlay {
  position: fixed;
  top: 0;
  left: 0;
  width: 100vw;
  height: 100vh;
  z-index: 999;
  background: rgba(0, 0, 0, 0.7);
  display: flex!important;
  align-items: center;
  justify-content: center;
}
.hd-external-link-overlay__wrapper {
  width: 85%;
  max-width: 800px;
}
.hd-external-link-overlay__close {
  width: 30px;
  height: 30px;
  background: url(../images/close-overlay.b90d6f08.svg);
  background-repeat: no-repeat;
  background-size: contain;
  background-position: 50%;
  margin-left: auto;
  cursor: pointer;
  position: absolute;
  top: 10px;
  right: 10px;
}
.hd-external-link-overlay__content {
  margin: 1em 0;
  background: #fff;
  padding: 2em 5em;
  max-height: 80vh;
  overflow-y: auto;
  text-align: center;
  position: relative;
}
.hd-external-link-overlay__title {
  font-size: 1.5em;
  font-weight: 600;
  margin: 1em 0;
}
.hd-external-link-overlay__copy {
  font-size: 1.1em;
}
.hd-external-link-overlay__controls {
  display: flex;
  align-items: center;
  justify-content: center;
  margin: 3em 0 1em 0;
}
.hd-external-link-overlay__controls--button {
  color: #fff;
  background: #4c4948;
  padding: 10px;
  border-radius: 20px;
  min-width: 130px;
  margin: 0 10px;
  cursor: pointer;
}
.hd-external-link-overlay__controls--button:hover,
.hd-external-link-overlay__controls--button:active,
.hd-external-link-overlay__controls--button.primary {
  background: #e10;
  color: #fff;
  text-decoration: none;
}
.hd-external-link-overlay p {
  margin-bottom: 0;
}
.hd-external-link-overlay__controls--button p {
  color: #fff;
}
@media screen and (max-width: 767px) {
  .hd-external-link-overlay__content {
    padding: 2em 2em;
    font-size: 0.9em;
  }
  .hd-external-link-overlay__controls--button {
    margin: 10px 5px;
    min-width: 100px;
  }
}

.user-register-form #edit-actions {
  width: 100%;
}

.user-register-form #edit-actions button[type='submit'] {
  width: 100%;
  border-radius: 4px!important;
}

.user-register-form a.btn.link-already-account {
  background-color: #ffffff;
  color: var(--primary-color);
  border-color: var(--primary-color);
}

button, .btn {
  border-radius: 0.5rem!important;
}

.webform-submission-form {
  max-width: 642px;
  width: 100%;
  font-weight: 400;
  font-size: 16px;
  line-height: 140%;
  color: #4F4F4F;
  margin: 0 auto;
}

@media screen and (max-width: 768px){
  .webform-submission-form {
    padding: 0 15px;
  }
}

.webform-submission-form input[type=text],
.webform-submission-form input[type=number],
.webform-submission-form input[type=date],
.webform-submission-form input[type=tel],
.webform-submission-form select,
.webform-submission-form textarea,
.webform-submission-form input[type=email] {
  width: 100%;
  background: #FFFFFF;
  border: 1px solid #E4E4E4;
  padding: 11px 12px;
  height: auto;
  border-radius: unset;
}

.webform-submission-form .form-composite > legend, .label {
  font-weight: normal;
}

.webform-submission-form .form-type-checkbox > label {
  font-style: italic;
  font-weight: 400;
  font-size: 16px;
  line-height: 130%;
  color: #58595B;
  margin: 0 0 0 8px;
}

.webform-submission-form #edit-actions {
  display: flex;
  justify-content: center;
}

.webform-submission-form input[type=submit] {
  font-style: normal;
  font-weight: 700;
  font-size: 16px;
  line-height: 140%;
  text-align: center;
  text-transform: uppercase;
  padding: 18px 34px 18px 33px;
  border: none;
}
.webform-submission-form .form-type-checkbox > label,
.webform-submission-form #edit-policy-all p.text-disclaimer,
.webform-submission-form #edit-contact-policy {
  font-style: italic;
  font-weight: 400;
  font-size: 12px;
  line-height: 130%;
  color: #58595B;
}
.webform-submission-form #edit-policy-all p.text-disclaimer {
  margin-left: unset;
  margin-bottom: 12px;
}
.webform-submission-form #edit-policy-all a {
  color: #58595B;
  font-style: italic;
  font-weight: 400;
  font-size: 12px;
  line-height: 130%;
  text-decoration: underline;
}

.webform-submission-form .form-type-checkbox .description {
  margin-left: 0;
}

main.user-login-page .article-panel .card-small-image .image-wrapper img,
main.user-login-page .article-panel .card-img-top-wrapper .card-img-wrapper img,
main.user-login-page .article-panel .card-img-top-wrapper .video-thumb img,
main.user-login-page .article-panel .card-carousel .card-img-wrapper img,
main.user-login-page .article-panel .card-carousel .video-thumb img {
  height: 250px;
}

main.user-login-page .article-panel .pillars .card-img-wrapper {
  height: 250px;
}

main.user-login-page .article-panel .card-img-top-wrapper .image-wrapper {
  height: 250px;
}

.path-user main ul li:before {
  display: none!important;
}

.block-layout-builder ul#myTab li {
  padding: 10px 0;
  border-bottom: 3px solid transparent;
}
.nav-item a {
  color: #495057;
}

.nav-tabs .nav-link {
  font-size: 20px;
}
